题 目：Bio-Fabrication of Scaffolds for Tissue Engineering Applications
Tissue engineering is an emerging field with the aim of producing ‘artificial’ tissue or organ substitutes that can grow with patients, ultimately providing a permanent solution to damaged tissues or organs. In tissue engineering, tissue scaffolds play a crucial role. A tissue scaffold is a three-dimensional (3D) structure made from biomaterials with a highly interconnected pore network or microstructure that is used to facilitate cell growth and transport of nutrients and wastes while degrading gradually itself. Fabrication of scaffolds has proven to be a challenging task. One important barrier is the inability to fabricate scaffolds with a microstructure and spatially-controlled distribution of cells that mimics the structure and cell organization in native tissues, and with both mechanical and biological properties appropriate for tissue engineering applications. Recently, the speaker’s research group has been very active to pursue research on bio-fabrication scaffolds for various tissue engineering applications, including the repair peripheral nerve injuries, spinal cord injuries, articular cartilage, and myocardial infarction. In this presentation, the speaker will report their recent work and achievements, and discuss the challenges and the opportunities in this emerging field. The promising of the use synchrotron–based imaging to track scaffold placement and success in living tissue will also be discussed.
Dr. Daniel Chen is currently a Professor with the Department of Mechanical Engineering and the Division of Biomedical Engineering, both at theUniversityofSaskatchewan. He is also the leader of Tissue Engineering Research Group that consists of a number of researchers spanning both engineering and health sciences at his University. He is the recipient of the award for Research Achievement in Engineering 2014 fromCollegeofEngineeringand the New Research Award 2012 of theUniversityofSaskatchewan, both recognizing his scientific contributions and achievements. His research interests includeBio-fabrication of Scaffolds,Tissue Engineering,Precision Fluid Manipulation,Mechatronics and Bio-Mechatronics, andNano-Positioning. His research has been supported by the Natural Sciences and Engineering Research Council (NSERC) ofCanada, Canadian Institutes of Health Research (CIHR), Canada Foundation for Innovation (CFI), Saskatchewan Health Research Foundation (SHRF), and National Natural Science Foundation of China (NSFC).